Of course, the opponent matters, so I will never say “never”, but all things being equal, why would anyone NOT drive straight through LV and on to SD, or better yet, spend a little more on airfare and a car rental.
Las Vegas is a $#ithole, and always will be. The weather is usually questionable, especially compared to SD, and even if the Vegas game is rescheduled for NY weekend, matching the Holiday Bowl, still, WHY WOULD VEGAS EVER BE BETTER THAN SD?
Obviously, I’m not a gambler, so if gambling is your answer, I quickly defer.
Otherwise, it is NO CONTEST!